Ion Channel Pharmacology

 

Ion channels are involved in many cellular processes, drugs acting on ion channels have long been used for the treatment of many diseases, especially those affecting electrically excitable tissues. Combined with advancements in high throughput screening of ion channels in drug discovery, elucidating ion channel pharmacology has grown into an enormous global task. Because of the high information content, voltage clamp is the best way to study ion-channel function which is superbly provided by the HEKA and NPI systems.

Ion channel pharmacology is ultimately dependent upon the application of the particular drug in question. Such drug application is provided depending on your needs. Computer controlled local perfusion is provided by ALA Octaflow and VC3   systems. Submillisecond application of drugs can be achieved by the ALA HSSE-2 system. Your drug of choice can also be applied to the internal of cells during whole cell recording using the ALA 2PK+ system. A wide variety of manifolds, perfusion chambers and other accessories allows the ion channel pharmacologist to easily design a system to suit their requirements.

 

Classical compound application

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Pipette internal solution exchange

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