4 channel rapid temperature exchange device for studies of temperature-gated ion channels

The cloning and initial characterization of ion channels directly gated by temperature has generated tremendous excitement in the neuroscience community. Studying these important channels requires instruments that are not only capable of very rapid temperature change in the extracellular milieu of the voltage-clamped cell, but are also able to meet the exacting space and noise requirements of patch-clamp applications. In response to customer requests, ALA Scientific Instruments now presents the High-Speed 4-channel Temperature Clamp system (HSTC-4).

4 channel rapid temperature exchange device for studies of temperature-gated ion channels

The cloning and initial characterization of ion channels directly gated by temperature has generated tremendous excitement in the neuroscience community. Studying these important channels requires instruments that are not only capable of very rapid temperature change in the extracellular milieu of the voltage-clamped cell, but are also able to meet the exacting space and noise requirements of patch-clamp applications. In response to customer requests, ALA Scientific Instruments now presents the High-Speed 4-channel Temperature Clamp system (HSTC-4). Together with the High-Speed Pressure Clamp (HSPC-1), the HSTC-4 establishes ALA as the leader in instruments for biophysical studies of sensory mechanisms under voltage-clamp control.

High Speed Temperature Clamp System can generate very fast temperature jumps. This system uses a proprietary front end that enables rapid temperature switching of solutions applied from a focal application device. The output of the device is applied to excised membrane patches under patch clamp, or to individual cells voltage-clamped by discontinuous single-electrode voltage clamp or patch clamp. The system consists of the BPS-4PP, 4 channel pressurized perfusion system, 2 npi PTC-20 heat/cool Peltier temperature controllers, PR-10 pressure regulator system, cooling pump, and ALA’s new High Speed 4 Channel Thermal Stimulator Front End.

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